ANALISIS HEMODIALISIS TERHADAP KREATININ DARAH PADA PASIEN GAGAL GINJAL KRONIS DI RSUD DRAJAT PRAWIRANEGARA

ABSTRACT

Diagnosis of kidney failure can be done by assessing the levels of creatinine and urea in serum, because both can only be excreted by the kidneys. The breakdown of creatinine produces nitrogen-containing compounds that remain in the muscles. One of the appropriate therapies for patients with chronic kidney disease is hemodialysis therapy. A study has been conducted to determine the effect of hemodialysis on creatinine levels. The sample was 21 male patients over 45 years of age undergoing hemodialysis at Drajat Prawiranegara Hospital, Serang. The creatinine levels of the samples were measured before and after hemodialysis. The method of measuring creatinine is the Jaffe method without deproteination. The results were then compared to see the decrease in creatinine levels that reflect the effect of hemodialysis on creatinine levels. The data were tested for normality, homogeneity, and continued with a paired t-test. The highest creatinine level before hemodialysis was 17.33 mg/dl and the lowest was 6.24 mg/dl. The highest creatinine level after hemodialysis was 8.71 mg/dl and the lowest was 1.88 mg/dl. The creatinine level after hemodialysis was still above normal but there had been a decrease in creatinine levels. The result was a decrease in creatinine levels of 57% and the two data groups were significantly different. This means that there is an effect of hemodialysis on creatinine levels. So that health workers can convince patients not to hesitate to undergo hemodialysis if needed.
Keywords: hemodialysis, creatinine, Jaffe method.