PERBEDAAN HASIL KADAR KREATININ PADA SAMPEL SERUM, PLASMA EDTA DAN PLASMA HEPARIN METODE SARKOSIN OXIDASE

ABSTRACT
Creatinine is a byproduct of muscle catabolism, originating from the breakdown of
muscle keratin phosphorus. The amount of creatinine produced is proportional to
muscle mass. Creatinine is filtered by the glomerulus and excreted in the urine.
Examination of blood creatinine levels is one of the parameters used to assess
kidney function. The examination uses serum but in certain circumstances
sometimes uses plasma heparin and EDTA samples. The aim of this study was to
analyze differences in creatinine examination results using serum, heparin and
EDTA. Analytical research method, research subjects 15 samples. Samples were
each treated as serum, plasma heparin and EDTA and then checked for creatinine
levels. The results of the Shapiro Wilk Test showed that the data on serum samples,
EDTA plasma and Heparnine plasma were 0.142, 0.132 and 0.190, all three groups
showed values > 0.05, so the data was normally distributed, followed by the
Creatinine Homogeneity Test, which was 0.759 > 0.05, so the data were
homogeneous. Next, analyzed using the Oneway Anova Test, the significance value
was 0.916 > 0.05. The conclusion was that there was no difference in creatinine
levels in serum sampels, EDTA plasma and heparin plasma.

Keywords: Creatinine levels, Serum, Plasma EDTA, heparin.