HUBUNGAN NILAI SERUM GLUTAMIC OXALOACETIC TRANSMINASE (SGOT) DAN SERUM GLUTAMIC PYRUVIC TRANSMINASE (SGPT) DENGAN SERUM YANG REAKTIF HBSAG DI KLINIK TIRTA MEDICAL CENTRE

Hepatitis is still a world health problem. According to the Ministry of Health, in 2023 more than 20 million cases of Hepatitis B will occur in Indonesia. Hepatitis can interfere with liver function and cause liver damage, which is called liver necrosis. HBsAg examination accompanied by SGOT and SGPT can be an initial screening to determine liver function disorders due to the Hepatitis B virus or to monitor the effectiveness of therapy in patients who are already infected. This study tested the relationship between SGOT and SGPT with HBsAg titers using the Chi Square test. Of the 23 samples, the majority of SGOT and SGPT activities were normal (34.8%). In the Chi Square test the results were p SGOT – HBsAg 0.022 < 0.05 and p SGPT – HBsAg 0.002 < 0.05. This means that there is a relationship between SGOT and SGPT with HBsAg titer. Liver damage that reaches the mitochondria causes an increase in the SGOT enzyme. The process of eliminating the Hepatitis B virus is liver cell necrosis due to a specific immune response from T and B lymphocyte cells causing an increase in SGPT. When the infection is chronic, the body will lose immune tolerance and cause an increase in liver enzymes. Normal SGOT and SGPT indicate an initial infection that has a healthy prognosis or a Hepatitis B patient with treatment.

Key word : HBsAg, SGOT, SGPT