PERBANDINGAN KADAR BILIRUBIN TOTAL, DIREK, INDIREK METODE VANADATE OXIDATION PADA BAYI IKTERUS SEBELUM DAN SESUDAH FOTOTERAPI

Newborn babies require an adaptation process from life in the womb to life outside the womb. During this process, physiological changes will occur in the newborn baby. Neonatal jaundice is jaundice in babies. This disease is caused by the accumulation of bilirubin in body tissues. Phototherapy itself is a light therapy in the form of treatment for the skin using artificial wavelengths of ultraviolet light, namely therapy using light that can be observed with the aim of treating babies with hyperbilirubinemia in neonates. The use of phototherapy is one of the hyperbilirubinemia therapies that is effective in reducing indirect bilirubin levels before they cause kernicterus. The results of this study showed that there were differences where Total Bilirubin before 18.07 mg/dL after 10.35 mg/dL, Direct Bilirubin before 0.81 mg/dL after 0.69 mg/dL, Indirect Bilirubin before 17.34 mg/dL after 9.74 mg/dL. After statistical testing using the T Test or Paired Sample T-Test on the amount of bilirubin before and after phototherapy, a significant result of 0.00 was obtained, which means there was a difference in total, direct and indirect ilirubin levels before and after phototherapy. This is caused by UV light in phototherapy changing tetrapyrrole compounds which are difficult to dissolve in air into dipyrrole compounds which are easily soluble in air and excreted through feces and urine. It can be concluded that there are differences in total, direct and indirect bilirubin levels before and after phototherapy.

Keywords: Jaundice baby, Bilirubin, Phototherapy.