ANALISIS GLIKOPROTEIN (GP120) HUMAN IMMUNODEFICIENCY VIRUS (HIV-1) UNTUK MENDAPATKAN PEPTIDA AKTIVATOR SEL B MELALUI PENDEKATAN IMUNOINFORMATIKA

HIV-1, as the main cause of acquired immunodeficiency syndrome (AIDS), remains a global health problem with a high mortality rate. Vaccine development for HIV has been a major challenge for more than four decades without an effective vaccine. This study aims to identify peptide-based vaccine candidates from the HIV-1 gp120 protein using an immunoinformatic approach. The method used involves in silico analysis to predict peptide epitopes that can activate B cells. The gp120 protein sequence was retrieved from the NCBI database (code: NP_057856.1) and analysed using IEDB AR software for epitope prediction, and ToxinPred and AllerCatPro for toxicity and allergenicity analysis. The results of the analysis showed that of the 9 candidate peptides identified, the peptide "GGNSNNESEIFRPGGGDMRDNWRSELYKY" with a length of 29 residues has the greatest potential to activate B cells. All peptides tested were declared Non�Toxic and non-allergenic, making them safe for biological applications.

Keywords: HIV-1, gp120, peptide vaccine, immunoinformatics, B cells, epitopes